Life sciences companies engage in considerable, and often exclusively in, research and development activity. Not surprisingly, these companies often face unique challenges relating to R&D — from make-or-build vs. buy decisions, contract research and contract development, and manufacturing arrangements — as they progress through the clinical stages to commercial operations. The R&D landscape for life sciences companies is further complicated by additional challenges brought on by digital transformations, competitive intelligence, market research and M&A activity.

The life sciences industry is directly affected by the new federal tax amortization provisions for research and experimental (R&E) expenditures. Under the 2017 Tax Cuts and Jobs Act (TCJA), R&E expenditures incurred or paid for tax years beginning after December 31, 2021, will no longer be immediately deductible for tax purposes. Instead, businesses are now required to capitalize and amortize R&E expenditures over a period of five years for research conducted within the U.S. or 15 years for research conducted in a foreign jurisdiction. The new mandatory capitalization rules also apply to software development costs, regardless of whether the software is developed for sale or license to customers or for internal use.

Tax Implications of Mandatory Capitalization Rules

Under the new mandatory capitalization rules, amortization of R&E expenditures begins from the midpoint of the taxable year in which the expenses are paid or incurred, resulting in a negative Year 1 tax and cash flow impact when compared to the previous rules that allowed an immediate deduction.

For example, assume a calendar-year biopharmaceutical company incurs $50 million of U.S. R&E expenditures in 2022. Prior to the TCJA amendment, the company would have immediately deducted all $50 million of expense on its tax return. Under the new rules, however, the company will be entitled to deduct amortization expense of only $5 million beginning in 2022 ($50 million/five years/2 for the midpoint convention). The example’s $45 million decrease in Year 1 deductions emphasizes the magnitude of the impact of the new rules on life sciences companies that engage directly or indirectly (through certain contract arrangements) in research and development.

The new rules present additional issues for consideration by businesses that invest in R&E, which are discussed below.

Cost/Benefit of Offshoring R&E Activities

As noted above, R&E expenditures incurred for activities performed overseas are subject to an amortization period of 15 years, as opposed to a five-year amortization period for R&E activities carried out in the U.S. Given the prevalence of outsourcing R&E and software development activities to foreign jurisdictions, taxpayers that currently incur these costs outside the U.S. are likely to experience an even more significant impact from the new rules than their counterparts that conduct R&E activities domestically. Businesses should carefully consider the tax impact of the longer 15-year recovery period when weighing the cost savings from shifting R&E activities overseas. Further complexities may arise if the entity that incurs the foreign R&E expenditures is a foreign corporation owned by a U.S. taxpayer, as the new mandatory capitalization rules may also increase the U.S. taxpayer’s global intangible low-taxed income (GILTI) inclusion.

Identifying and Documenting R&E Expenditures

Unless repealed or delayed by Congress (see below), the new mandatory amortization rules apply for tax years beginning after December 31, 2021. Taxpayers with R&E activities should begin assessing what actions are necessary to identify qualifying expenditures and to ensure compliance with the new rules. Some taxpayers may be able to leverage from existing financial reporting systems or tracking procedures to identify R&E; for instance, companies may already be identifying certain types of research costs for financial reporting under ASC 730 or calculating qualifying research expenditures for purposes of the research tax credit. Companies that are not currently identifying R&E costs for other purposes may have to undertake a more robust analysis, including performing interviews with operations and financial accounting personnel and developing reasonable allocation methodologies to the extent that a particular expense (e.g., rent) relates to both R&E and non-R&E activities.

Importantly, all taxpayers with R&E expenditures, regardless of industry or size, should gather and retain contemporaneous documentation necessary for the identification and calculation of costs amortized on their tax return. This documentation can play a critical role in sustaining a more favorable tax treatment upon examination by the IRS as well as demonstrating compliance with the tax law during a future M&A due diligence process.

Acquisition and Exit Scenario Considerations

The significant differences in timing of deductions between Internal Revenue Code Section 174 R&E costs and other currently deductible costs may become a significant consideration in the context of acquisitions.  In a stock acquisition, preexisting tax bases will carry over. Therefore, if a selling company was not compliant in identifying and capitalizing pre-acquisition Section 174 costs, the buyer would not gain the post-acquisition benefit of deducting the amortization of pre-acquisition R&E deferred tax assets that were not identified or capitalized by the seller. The buyer may also be on the hook, upon IRS examination, to pay additional tax liabilities for improper seller deductions of R&E costs in pre-acquisition periods. Accordingly, buyers and sellers should be conscious of this issue in due diligence and preparation for an exit, and consider whether establishing tax contingency/escrow provisions is necessary.

Impact on Financial Reporting under ASC 740

Taxpayers also need to consider the impact of the mandatory capitalization rules on their tax provisions. In general, the addback of R&E expenditures in situations where the amounts are deducted currently for financial reporting purposes will create a new deferred tax asset. Although the book/tax disparity in the treatment of R&E expenditures is viewed as a temporary difference (the R&E amounts will eventually be deducted for tax purposes), the ancillary effects of the new rules could have other tax impacts, such as on the calculation of GILTI inclusions and foreign-derived intangible income (FDII) deductions, which ordinarily give rise to permanent differences that increase or decrease a company’s effective tax rate. The U.S. valuation allowance assessment for deferred tax assets could also be affected due to an increase in taxable income. Further, changes to both GILTI and FDII amounts should be considered in valuation allowance assessments, as such amounts are factors in forecasts of future profitability.


The new mandatory capitalization rules for R&E expenditures and the resulting increase in taxable income will likely impact the computation of quarterly estimated tax payments and extension payments owed for the 2022 tax year. Even taxpayers with net operating loss (NOL) carryforwards should be aware of the tax implications of the new rules, as they may find themselves utilizing more NOLs than expected in 2022 and future years, or may end up in a taxable position if the deferral of the R&E expenditures is material (or if NOLs are limited under IRC Section 382 or the TCJA). In such instances, companies may find it prudent to examine other tax planning opportunities, such as performing an R&D tax credit study or assessing their eligibility for the FDII deduction, which may help lower their overall tax liability.

Will the new rules be delayed?

The version of the Build Back Better Act that was passed by the U.S. House of Representatives in November 2021 would have delayed the effective date of the TCJA’s mandatory capitalization rules for R&E expenditures until tax years beginning after December 31, 2025. While this specific provision of the House bill enjoyed broad bipartisan support, the BBBA bill did not make it out of the Senate, and recent comments by some members of the Senate have indicated that the BBBA is unlikely to become law in its latest form. Accordingly, as of the date of this publication, the original effective date contained in the TCJA for the mandatory capitalization of R&E expenditures –taxable years beginning after December 31, 2021, — remains in place.

Written by Connie Cunningham, Peter Pentland and Eleni Lagos. Copyright © 2022 BDO USA, LLP. All rights reserved. 


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